Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype.

doi:10.1016/S0006-3495(95)79962-3

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Article

Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype.

Biophysical journal - 1 Sept 1995

Wei L Y, Stutts M J, Hoffman M M, Roepe P D

Abstract excerpt

Because of the similarities between the cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance (MDR) proteins, recent observations of decreased plasma membrane electrical potential (delta psi) in cells overexpressing either MDR protein or the CFTR, and the effects of...

Topics

3T3 Cells
Affinity Labels
Animals
Azides
Base Sequence
Colchicine
Cystic Fibrosis Transmembrane Conductance Regulator
DNA Primers
DNA, Complementary
Dihydropyridines
Doxorubicin
Drug Resistance, Multiple

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fluoresceins

Fluorescent Dyes

Gene Expression

Humans

Hydrogen-Ion Concentration

Membrane Potentials

Source

Open in PubMed Open full text

Identifiers

PMID: 8519988
DOI: 10.1016/S0006-3495(95)79962-3
PMCID: PMC1236317

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8519988-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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