Article
Assessment of multidrug resistance reversal using dielectrophoresis and flow cytometry.
Biophysical journal - 1 Sept 2003
Labeed Fatima H, Coley Helen M, Thomas Hilary, Hughes Michael P
Abstract excerpt
In cancer, multidrug resistance (MDR) is the simultaneous resistance of tumor cells to different natural product anticancer drugs that have no common structure. This is an impediment to the successful treatment of many human cancers. A common correlate of MDR is the overexpression of a membrane protein, P-glycoprotein. Many studies have shown that MDR can be reversed after the use of substrate analogs, called MDR...
Topics
- Blotting, Western
- Cell Line, Tumor
- Coloring Agents
- Cytoplasm
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Electrophoresis
- Flow Cytometry
- Humans
- Inhibitory Concentration 50
- K562 Cells
- Microscopy, Video
- Phenotype
- Protein Conformation