Article
Transfection of mu MDR 1 inhibits Na(+)-independent Cl-/-HCO3 exchange in Chinese hamster ovary cells.
Biochemistry - 14 Jun 1994
Luz J G, Wei L Y, Basu S, Roepe P D
Abstract excerpt
We have used single-cell photometry to measure intracellular pH (pHi) for several MDR cell lines constructed by stably transfecting LR73 chinese hamster ovary fibroblasts with mutant and wild type murine MDR 1 genes. In addition, plasma membrane electrical potential (delta psi) has been measured...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antiporters
- Bicarbonates
- CHO Cells
- Carrier Proteins
- Chloride-Bicarbonate Antiporters
- Chlorides
- Cricetinae
- Cricetulus
- Drug Resistance
- Hydrogen-Ion Concentration
- Membrane Glycoproteins
- Membrane Potentials
- Mice
- Phenotype
- Sodium
- Transfection