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Article

Low external pH and osmotic shock increase the expression of human MDR protein.

Biochemistry - 14 Jun 1994

Wei L Y, Roepe P D

Abstract excerpt

We have studied the effects of extracellular pH (pHo) and osmotic strength on the expression of the human multidrug resistance (MDR) protein. Both lowered pHo and hypertonic shock increase the level of hu MDR protein 5-10-fold in membranes isolated from the human colon carcinoma cell lines SW620 and HCT15 and the human kidney carcinoma line SKRC-39. Increased protein expression is dependent on the duration of...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Carrier Proteins
Colonic Neoplasms
Drug Resistance
Gene Expression Regulation
Humans
Hydrogen-Ion Concentration
Kidney Neoplasms
Membrane Glycoproteins
Osmotic Pressure
Phenotype

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Tumor Cells, Cultured

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Identifiers

PMID: 7911681
DOI: 10.1021/bi00189a027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7911681-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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