Article
Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Apr 2011
Fracalossi Ana C C, Comparini Larissa, Funabashi Karina, Godoy Carla, Iwamura Edna S M, Nascimento Fábio D, Nader Helena B, Oshima Celina T F, Ribeiro Daniel A
Abstract excerpt
BACKGROUND: The aim of this study was to investigate whether mutations in the genes H-ras and K-ras were related to the mechanism of invasion as a result of the immunoexpression of H-Ras, Ki-67, alpha-smooth muscle actin (SMA) and vascular endothelial growth factor (VEGF) during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. METHODS: Male Wistar rats were distributed into three groups of 10...
Topics
- 4-Nitroquinoline-1-oxide
- Actins
- Animals
- Cell Transformation, Neoplastic
- Genes, ras
- Ki-67 Antigen
- Male
- Mutation
- Neoplasm Invasiveness
- Neoplasms, Experimental
- Rats
- Rats, Wistar