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Article

Loss of expression of basement membrane proteins reflects anomalies of chromosomes 3 and 12 in the rat 4-nitroquinoline-N-oxide model of oral carcinogenesis.

Carcinogenesis - 1 Jan 1995

Patel V, Poulopoulos A K, Levan G, Game S M, Eveson J W, Prime S S

Abstract excerpt

This study examined the cytogenetic characteristics of keratinocyte cell lines derived from rat oral tissues treated in vivo with the carcinogen 4-nitroquinoline-N-oxide. A parent tumour with a spectrum of differentiation was used to establish clonal subpopulations that formed differentiated (squamous cell carcinomas; SCCs) and undifferentiated (spindle cell phenotype) tumours following transplantation to athymic...

Topics

3T3 Cells
4-Nitroquinoline-1-oxide
Animals
Basement Membrane
Carcinoma
Carcinoma, Squamous Cell
Cell Differentiation
Chromosome Aberrations
Clone Cells
Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Karyotyping

Male

Membrane Proteins

Mice

Mice, Nude

Mouth Neoplasms

Neoplasm Proteins

Neoplasm Transplantation

Source

Identifiers

PMID: 7834801
DOI: 10.1093/carcin/16.1.17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7834801-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of expression of basement membrane proteins reflects anomalies of chromosomes 3 and 12 in the rat 4-nitroquinoline-N-oxide model of oral carcinogenesis.PMID 7834801Read ↗

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