Article
Disruptive mRNA folding increases translational efficiency of catechol-O-methyltransferase variant.
Nucleic acids research - 1 Aug 2011
Tsao Douglas, Shabalina Svetlana A, Gauthier Josée, Dokholyan Nikolay V, Diatchenko Luda
Abstract excerpt
Catechol-O-methyltransferase (COMT) is a major enzyme controlling catecholamine levels that plays a central role in cognition, affective mood and pain perception. There are three common COMT haplotypes in the human population reported to have functional effects, divergent in two synonymous and one nonsynonymous position. We demonstrate that one of the haplotypes, carrying the non-synonymous variation known to...
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