Article
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
International journal of colorectal disease - 1 Oct 2011
Oltedal Satu, Aasprong Ole Gunnar, Møller Jannicke H, Kørner Hartwig, Gilje Bjørnar, Tjensvoll Kjersti, Birkemeyer Elke M, Heikkilä Reino, Smaaland Rune, Nordgård Oddmund
Abstract excerpt
PURPOSE: K-ras mutations predict resistance against epidermal growth factor receptor (EGFR)-directed therapy of metastatic colorectal cancer (CRC). The purpose of this study was to analyze the distribution of K-ras mutations in primary tumors and corresponding sentinel lymph nodes (SLNs) from colon cancer patients. METHODS: Tumor biopsies and SLNs from 158 patients with non-metastatic colon cancer were analyzed...
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