Article
No association between 12 dopaminergic genes and schizophrenia in a large Dutch sample.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2005
Hoogendoorn Mechteld L C, Bakker Steven C, Schnack Hugo G, Selten Jean-Paul C, Otten Henny G, Verduijn Willem, van der Heijden Frank M M A, Pearson Peter L, Kahn René S, Sinke Richard J
Abstract excerpt
It has been suggested that genes involved in dopamine neurotransmission contribute to the pathogenesis of schizophrenia. However, reported associations of the disorder with genetic markers in dopaminergic genes have yielded inconsistent results. Possible explanations are differences in phenotyping, genetic heterogeneity, low marker informativity, and the use of small sample sizes. Here, we present a two-stage...
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