Article
Linkage analysis of the D1 dopamine receptor gene and manic depression in six families.
Human heredity - 1 Jan 1992
Jensen S, Plaetke R, Holik J, Hoff M, O'Connell P, Reimherr F, Wender P, Zhou Q Y, Civelli O, Litt M
Abstract excerpt
Disturbances in dopaminergic activity may play an important role in the pathogenesis of manic depression. The effects of dopamine are mediated by at least five G protein coupled receptors, D1, D2, D3, D4 and D5. Recently, three separate research groups have cloned and characterized the D1 dopamin...
Topics
- Bipolar Disorder
- Genetic Linkage
- Genotype
- Humans
- Lod Score
- Phenotype
- Polymorphism, Restriction Fragment Length
- Receptors, Dopamine D1