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Article

Linkage analysis of the D1 dopamine receptor gene and manic depression in six families.

Human heredity - 1 Jan 1992

Jensen S, Plaetke R, Holik J, Hoff M, O'Connell P, Reimherr F, Wender P, Zhou Q Y, Civelli O, Litt M

Abstract excerpt

Disturbances in dopaminergic activity may play an important role in the pathogenesis of manic depression. The effects of dopamine are mediated by at least five G protein coupled receptors, D1, D2, D3, D4 and D5. Recently, three separate research groups have cloned and characterized the D1 dopamine receptor, which localizes to 5q35.1. We undertook a linkage analysis between the D1 receptor polymorphisms and manic...

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Identifiers

PMID: 1360940
DOI: 10.1159/000154081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Linkage analysis of the D1 dopamine receptor gene and manic depression in six families.PMID 1360940Read ↗

Linkage analysis of schizophrenia: the D1 dopamine receptor gene and several flanking DNA markers.Semantic proximity Read ↗

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A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.Semantic proximity Read ↗

Exclusion of linkage between manic depressive illness and tyrosine hydroxylase and dopamine D2 receptor genes.Semantic proximity Read ↗

Mutation scan of the D1 dopamine receptor gene in 22 cases of bipolar I disorder.Semantic proximity Read ↗

A linkage study with D5 dopamine and alpha 2C-adrenergic receptor genes in six multiplex bipolar pedigrees.Semantic proximity Read ↗

Linkage analysis between manic-depressive illness and 35 classical markers.Semantic proximity Read ↗

Tyrosine hydroxylase gene not linked to manic-depression in seven of eight pedigrees.Semantic proximity Read ↗

The impact of phenotypic variation on genetic analysis: application to X-linkage in manic-depressive illness.Semantic proximity Read ↗

A search for genes predisposing to manic depressive illness on chromosome 20.Semantic proximity Read ↗

Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia.Semantic proximity Read ↗

A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP.Semantic proximity Read ↗

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