Cell cycle checkpoints, genetic instability and cancer.

Article

Cell cycle checkpoints, genetic instability and cancer.

Seminars in cancer biology - 1 Apr 1993

Weinert T, Lydall D

Abstract excerpt

During the cell cycle, the order of events is maintained by controls termed checkpoints. Two checkpoints are sensitive to DNA damage, one that acts before mitosis and a second that acts before DNA replication. This is relevant to cancer because checkpoint mutants show genetic instability, and suc...

Topics

Animals
Cell Cycle
DNA Damage
DNA Replication
Humans
Mutation
Neoplasms
Neoplasms, Experimental

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