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Cell cycle checkpoints, genetic instability and cancer.

Seminars in cancer biology - 1 Apr 1993

Weinert T, Lydall D

Abstract excerpt

During the cell cycle, the order of events is maintained by controls termed checkpoints. Two checkpoints are sensitive to DNA damage, one that acts before mitosis and a second that acts before DNA replication. This is relevant to cancer because checkpoint mutants show genetic instability, and such instability is characteristic of many cancers. Studies of checkpoints in normal and cancer cells suggest a...

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PMID: 8513148

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