Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Carboxyl domain of glutamate receptor directs its coupling to metabolic pathways.

Neuroreport - 1 May 1993

Gabellini N, Manev R M, Candeo P, Favaron M, Manev H

Abstract excerpt

Of the six metabotropic glutamate receptors (mGluRs) only mGluR1 and mGluR5, which possess a large carboxyl terminal domain, are positively linked to phosphoinositide (PI) hydrolysis. We expressed a 3' deletion of mGluR1 alpha (mGluR1T) lacking the terminal 290 codons and the full length mGluR1 alpha cDNAs in human embryonic kidney 293 cells. Agonist stimulation of both mGluR1 alpha and mGluR1T stimulated PI...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Cells, Cultured
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Kidney

Share to Mutation

Share to Signal Transduction

Share to Transcription, Genetic

Source

Identifiers

PMID: 8513133
DOI: 10.1097/00001756-199305000-00017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Carboxyl domain of glutamate receptor directs its coupling to metabolic pathways.PMID 8513133Read ↗

Involvement of the C-terminal domain in cell surface localization and G-protein coupling of mGluR6.Semantic proximity Read ↗

mGlu4 potentiation of K(2P)2.1 is dependant on C-terminal dephosphorylation.Semantic proximity Read ↗

Regulatory role of C-terminus in the G-protein coupling of the metabotropic glutamate receptor 1.Semantic proximity Read ↗

Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1.Semantic proximity Read ↗

Functional coupling of human metabotropic glutamate receptor hmGlu1d: comparison to splice variants hmGlu1a and -1b.Semantic proximity Read ↗

Differential internalisation of mGluR1 splice variants in response to agonist and phorbol esters in permanently transfected BHK cells.Semantic proximity Read ↗

Signaling specificity and kinetics of the human metabotropic glutamate receptorsSemantic proximity Read ↗

Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs.Semantic proximity Read ↗

Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.Semantic proximity Read ↗

G protein-coupled receptor kinases regulate metabotropic glutamate receptor 5 function and expression.Semantic proximity Read ↗

The second cytoplasmic loop of metabotropic glutamate receptor functions at the third loop position of rhodopsin.Semantic proximity Read ↗

Agonist-induced internalization of mGluR1alpha is mediated by caveolin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.