Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory role of C-terminus in the G-protein coupling of the metabotropic glutamate receptor 1.

Journal of neurochemistry - 1 Nov 2008

Tateyama Michihiro, Kubo Yoshihiro

Abstract excerpt

The signaling property of metabotropic glutamate receptor 1alpha (mGlu1alpha) is different from that of short-form splice variants. This could be caused by the exposure of a cluster of positively charged amino acid residues, RRKK, in the proximal C-tail which is thought to be masked by the long C...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Transformed
Share to Chromones
Share to Colforsin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Membrane Potentials

Share to Pertussis Toxin

Share to Potassium Chloride

Share to Receptors, Metabotropic Glutamate

Source

Identifiers

PMID: 18786167
DOI: 10.1111/j.1471-4159.2008.05672.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18786167-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory role of C-terminus in the G-protein coupling of the metabotropic glutamate receptor 1.PMID 18786167Read ↗

Effects of coexpression with Homer isoforms on the function of metabotropic glutamate receptor 1alpha.Semantic proximity Read ↗

G Protein-coupled receptor kinase 2 regulator of G protein signaling homology domain binds to both metabotropic glutamate receptor 1a and Galphaq to attenuate signaling.Semantic proximity Read ↗

Carboxyl domain of glutamate receptor directs its coupling to metabolic pathways.Semantic proximity Read ↗

Involvement of the C-terminal domain in cell surface localization and G-protein coupling of mGluR6.Semantic proximity Read ↗

The second cytoplasmic loop of metabotropic glutamate receptor functions at the third loop position of rhodopsin.Semantic proximity Read ↗

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.Semantic proximity Read ↗

Signaling specificity and kinetics of the human metabotropic glutamate receptorsSemantic proximity Read ↗

CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling.Semantic proximity Read ↗

Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction.Semantic proximity Read ↗

Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain.Semantic proximity Read ↗

Investigation of allosteric modulation mechanism of metabotropic glutamate receptor 1 by molecular dynamics simulations, free energy and weak interaction analysis.Semantic proximity Read ↗

Phosphorylation-independent regulation of metabotropic glutamate receptor 1 signaling requires g protein-coupled receptor kinase 2 binding to the second intracellular loop.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.