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Article

Agonist-induced internalization of mGluR1alpha is mediated by caveolin.

Journal of neurochemistry - 1 Oct 2009

Hong Yun Hwa, Kim Ji Young, Lee Jeong Ho, Chae Hong Gu, Jang Sung Soo, Jeon Ju Hong, Kim Chul Hoon, Kim Jun, Kim Sang Jeong

Abstract excerpt

Agonist-induced internalization of metabotropic glutamate receptors (mGluRs) plays an important role in neuronal signaling. Although internalization of mGluRs has been reported to be mediated by clathrin-dependent pathway, studies describing clathrin-independent pathways are emerging. Here, we report that agonist-induced internalization of mGluR1alpha is mediated by caveolin. We show that two caveolin-binding...

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PMID: 19627451
DOI: 10.1111/j.1471-4159.2009.06289.x

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