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Article

The Ashkenazi-Centric G334R Variant of TP53 is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model.

Molecular and cellular biology - 1 Jan 2024

Stieg David C, Casey Kaitlyn, Karisetty Bhanu Chandra, Leu Julia I-Ju, Larkin Fiona, Vogel Peter, Madzo Jozef, Murphy Maureen E

Abstract excerpt

Mutations in the TP53 tumor suppressor gene are the most abundant genetic occurrences in cancer. Some of these mutations lead to loss of function of p53 protein, some are gain of function, and some variants are hypomorphic (partially functional). Currently, there is no clinical distinction between different p53 mutations and cancer therapy or prognosis. Mutations in the oligomerization domain of p53 appear to be...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39520074
DOI: 10.1080/10985549.2024.2421885
PMCID: PMC11583612

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The Ashkenazi-Centric G334R Variant of TP53 is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model.PMID 39520074Read ↗

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