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Article

Re-engineered p53 chimera with enhanced homo-oligomerization that maintains tumor suppressor activity.

Molecular pharmaceutics - 7 Jul 2014

Okal Abood, Cornillie Sean, Matissek Stephan J, Matissek Karina J, Cheatham Thomas E, Lim Carol S

Abstract excerpt

The use of the tumor suppressor p53 for gene therapy of cancer is limited by the dominant negative inactivating effect of mutant endogenous p53 in cancer cells. We have shown previously that swapping the tetramerization domain (TD) of p53 with the coiled-coil (CC) from Bcr allows for our chimeric p53 (p53-CC) to evade hetero-oligomerization with endogenous mutant p53. This enhances the utility of this construct,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24836513
DOI: 10.1021/mp500202p
PMCID: PMC4114475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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