Induction of epidermal growth factor receptor gene transcription by transforming growth factor beta 1: association with loss of protein binding to a negative regulatory element.

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Article

Induction of epidermal growth factor receptor gene transcription by transforming growth factor beta 1: association with loss of protein binding to a negative regulatory element.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 1994

Hou X, Johnson A C, Rosner M R

Abstract excerpt

Transforming growth factor beta (TGF-beta) is a potent modulator of cell growth in many systems. In normal rat kidney fibroblasts, TGF-beta 1 increases epidermal growth factor (EGF) receptor gene transcription and synergizes with EGF to stimulate growth in soft agar, a characteristic of the trans...

Topics

Animals
Base Sequence
Cell Line
ErbB Receptors
Genes, Regulator
Humans
Molecular Sequence Data
Mutation
Promoter Regions, Genetic
Protein Binding
Proto-Oncogene Proteins c-fos
Rats
Transcription, Genetic
Transcriptional Activation
Transfection
Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 7986746

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7986746-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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