Article
Host genetics and resistance to acute Trypanosoma cruzi infection in mice. I. Antibody isotype profiles.
Parasite immunology - 1 Apr 1993
Powell M R, Wassom D L
Abstract excerpt
Some strains of inbred mice survive acute infection with Trypanosoma cruzi while others die within a few weeks after infection. Mice which express B10 background genes and either the H-2q or H-2d haplotypes are resistant and survive. However, mice which share the B10 genetic background but express H-2k alleles die, usually within 4 weeks following infection. These data confirm that at least 1 gene in the major...
Topics
- Acute Disease
- Animals
- Antibodies, Protozoan
- Antibody Specificity
- Blotting, Western
- Chagas Disease
- Enzyme-Linked Immunosorbent Assay
- Genetic Predisposition to Disease
- H-2 Antigens
- Immunity, Innate
- Immunoglobulin G