Article
A parent-of-origin effect determines the susceptibility of a non-informative F1 population to Trypanosoma cruzi infection in vivo.
PloS one - 1 Jan 2013
Silva Grace K, Cunha Larissa D, Horta Catarina V, Silva Alexandre L N, Gutierrez Fredy R S, Silva João S, Zamboni Dario S
Abstract excerpt
The development of Chagas disease is determined by a complex interaction between the genetic traits of both the protozoan parasite, T. cruzi, and the infected host. This process is regulated by multiple genes that control different aspects of the host-parasite interaction. While determination of the relevant genes in humans is extremely difficult, it is feasible to use inbred mouse strains to determine the genes...
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