Article
Linkage analysis: progress and problems.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jun 1994
Bishop D T
Abstract excerpt
Linkage analysis involves identifying the locations of genes responsible for disease by identifying other genes that co-segregate through families with the risk of disease. Subsequently, molecular approaches are applied to find the precise gene involved. Although these approaches have been successful to date, applications to diseases which do not show clear Mendelian inheritance have presented problems. The...
Topics
- Alleles
- Child
- Chromosome Mapping
- Family
- Female
- Genetic Linkage
- Genetic Markers
- Genetics, Medical
- Humans
- Male
- Models, Genetic
- Probability