Article
Predictions of T-cell receptor- and major histocompatibility complex-binding sites on staphylococcal enterotoxin C1.
Infection and immunity - 1 Aug 1994
Hoffmann M L, Jablonski L M, Crum K K, Hackett S P, Chi Y I, Stauffacher C V, Stevens D L, Bohach G A
Abstract excerpt
We have focused on regions of staphylococcal enterotoxin C1 (SEC1) causing immunomodulation. N-terminal deletion mutants lacking residues 6 through 13 induced T-cell proliferation similar to that induced by native toxin. However, mutants with residues deleted between positions 19 and 33, although nonmitogenic themselves, were able to inhibit both SEC1-induced T-cell proliferation and binding of the native toxin...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Cytokines
- Enterotoxins
- Histocompatibility Antigens Class II
- Humans
- Lymphocyte Activation
- Molecular Sequence Data
- Mutation
- Peptide Fragments