Article
Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Nov 2000
Burbano R R, Medeiros A C, Mello A A, Lemos J A, Bahia M O, Casartelli C
Abstract excerpt
Breast cancer in families with germ line mutations in the TP53 gene has been described in the medical literature. Mutation screening for susceptibility genes should allow effective prophylactic and preventive measures. Using single-strand conformational polymorphism, we screened for mutations in exons 5, 6, 7 and 8 of gene TP53 in the peripheral blood of 8 young non-affected members (17 to 36 years old) of...
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