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Article

High rate of multilocus deletion in a human tumor cell line.

Human molecular genetics - 1 Feb 1993

Harwood J, Tachibana A, Davis R, Bhattacharyya N P, Meuth M

Abstract excerpt

The nature of recessive mutations at the autosomal locus encoding the purine salvage enzyme adenine phosphoribosyl transferase (APRT) was analyzed in a highly malignant human tumor cell line (the colorectal carcinoma line SW620). Mutant strains resistant to the purine analog 8-azaadenine were obtained in two steps. The first step selection for partial drug resistance produced strains hemizygous for APRT as a...

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Source

Identifiers

PMID: 8499904
DOI: 10.1093/hmg/2.2.165

Genes

APRT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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