Single step selection of cis-diamminedichloroplatinum(II) resistant mutants from a human ovarian carcinoma cell line.

Article

Single step selection of cis-diamminedichloroplatinum(II) resistant mutants from a human ovarian carcinoma cell line.

Cancer research - 15 Apr 1991

McLaughlin K, Stephens I, McMahon N, Brown R

Abstract excerpt

We have shown that cis diamminedichloroplatinum-(II) (DDP) resistant mutants can be isolated from the human ovarian carcinoma cell line A2780 using a single-step selection protocol with DDP. DDP resistant colonies were calculated to be present at a frequency of 1.7 x 10(-6)/viable cell using a fl...

Topics

Aphidicolin
Buthionine Sulfoximine
Cell Survival
Cisplatin
Diterpenes
Drug Resistance
Female
Humans
Methionine Sulfoximine
Mutation
Ovarian Neoplasms
Phenotype
Tumor Cells, Cultured
Tumor Stem Cell Assay

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