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Article

Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene.

Nature genetics - 1 Jan 1993

Brown A G, Ross F M, Dunne E M, Steel C M, Weir-Thompson E M

Abstract excerpt

Roughly 25% of human B-cell chronic lymphocytic leukaemias (CLL) are characterized by a chromosomal lesion involving 13q14. This region contains the retinoblastoma gene (RB1). We have used a variety of techniques to determine whether RB1 or some other locus is the critical region in 11 cases of low grade B-cell malignancy (mainly CLL), all with deletions or translocations involving 13q14. In all cases, except the...

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Identifiers

PMID: 8490658
DOI: 10.1038/ng0193-67

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene.PMID 8490658Read ↗

Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

13q deletions in lymphoid malignanciesSemantic proximity Read ↗

Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia.Semantic proximity Read ↗

Alterations of the retinoblastoma a susceptibility gene in chronic lymphocytic leukemia.Semantic proximity Read ↗

Detailed Molecular Delineation of 13q14.3 Loss in B-Cell Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Minimal 16q Genomic Loss Implicates Cadherin-11 in RetinoblastomaSemantic proximity Read ↗

Frequent allelic loss of the RB, D13S319 and D13S25 locus in myeloid malignancies with deletion/translocation at 13q14 of chromosome 13, but not in lymphoid malignancies.Semantic proximity Read ↗

Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse linesSemantic proximity Read ↗

Mutations of the retinoblastoma gene in human lymphoid neoplasms.Semantic proximity Read ↗

Deletion of the human retinoblastoma gene in primary leukemias.Semantic proximity Read ↗

Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia.Semantic proximity Read ↗

Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia.Semantic proximity Read ↗

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