Article
Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia.
Oncogene - 1 Apr 1994
Chapman R M, Corcoran M M, Gardiner A, Hawthorn L A, Cowell J K, Oscier D G
Abstract excerpt
Cytogenetic studies of B-cell chronic lymphocytic leukaemia show structural abnormalities involving the 13q14 chromosome region as the only karyotypic change in a significant proportion of tumours. This observation suggests the location of a gene important in leukaemogenesis. A series of 68 BCLL...
Topics
- Alleles
- Autoradiography
- Chromosome Deletion
- Chromosomes, Human, Pair 13
- Genes, Tumor Suppressor
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Nucleic Acid Hybridization
- Translocation, Genetic