Article
Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia.
Blood - 15 Oct 1996
Bullrich F, Veronese M L, Kitada S, Jurlander J, Caligiuri M A, Reed J C, Croce C M
Abstract excerpt
Allelic loss at nonrandom chromosomal sites is thought to mark the position of tumor suppressor genes involved in the pathogenesis and progression of human malignancies. Solid tumors in particular have been found to harbor multiple genetic changes resulting in loss of function mutations. Tumor su...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Chromosomes, Human, Pair 13
- DNA Mutational Analysis
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Genetic Markers
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Microsatellite Repeats
- Polymerase Chain Reaction
- Sequence Deletion
