Article
Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia.
Genomics - 15 Jun 1997
Kalachikov S, Migliazza A, Cayanis E, Fracchiolla N S, Bonaldo M F, Lawton L, Jelenc P, Ye X, Qu X, Chien M, Hauptschein R, Gaidano G, Vitolo U, Saglio G, Resegotti L, Brodjansky V, Yankovsky N, Zhang P, Soares M B, Russo J, Edelman I S, Efstratiadis A, Dalla-Favera R, Fischer S G
Abstract excerpt
Frequent deletions and loss of heterozygosity in a segment of chromosome 13 (13q14) in cases of B-cell chronic lymphocytic leukemia (CLL) have suggested that this malignancy is caused by inactivation of an unknown tumor suppressor gene located in this region. Toward the identification of the putative CLL tumor suppressor, we have constructed a high-resolution physical map of YAC, PAC, and cosmid contigs covering...
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