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Article

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.

Protein engineering, design & selection : PEDS - 1 Jan 2012

Liu Wenhai, Onda Masanori, Kim Changhoon, Xiang Laiman, Weldon John E, Lee Byungkook, Pastan Ira

Abstract excerpt

Recombinant immunotoxins (RITs) are anti-cancer agents that combine the Fv of an antibody against cancer cells with a protein toxin from bacteria or plants. Since RITs contain a non-human protein, immunogenicity can be an obstacle in their development. In this study, we have explored the hypothesis that increasing stability can reduce the immunogenicity of a RIT using HA22-LR, which is composed of an anti-CD22 Fv...

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Identifiers

PMID: 22101015
DOI: 10.1093/protein/gzr053
PMCID: PMC3276307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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