Article
Targeted inactivation of p53 in human cells does not result in aneuploidy.
Cancer research - 15 Feb 2002
Bunz Fred, Fauth Christine, Speicher Michael R, Dutriaux Annie, Sedivy John M, Kinzler Kenneth W, Vogelstein Bert, Lengauer Christoph
Abstract excerpt
Because p53 mutation and aneuploidy usually coexist, it has been suggested that p53 inactivation leads to aneuploidy. We have rigorously tested this hypothesis in diploid human cell lines in which p53 was experimentally inactivated by targeted homologous recombination. Cells completely deficient in p53 did not become aneuploid, although a slight tendency toward tetraploidization was observed. No increased rates...
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