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Article

Reversal of In Vitro p53 Squelching by both TFIIB and TFIID

1 Nov 1995

Abstract excerpt

p53, the protein encoded by one of the most significant human tumor suppressor genes, is a sequence-specific transcriptional activator. When activated by a double-stranded DNA break, p53 function arrests cells in G1 and can induce apoptosis. Transcriptional activation function is critical for p53 tumor suppression, although transcriptional repressing and nontranscriptional functions of p53 may contribute. p53...

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PMID: 7565799
DOI: 10.1128/mcb.15.11.6474

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Reversal of In Vitro p53 Squelching by both TFIIB and TFIIDPMID 7565799Read ↗

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