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Article

How many mutant p53 molecules are needed to inactivate a tetramer?

Molecular and cellular biology - 1 Apr 2004

Chan Wan Mui, Siu Wai Yi, Lau Anita, Poon Randy Y C

Abstract excerpt

The tumor suppressor p53 is transcription factor composed of four identical subunits. The majority of the mutations in p53 are missense mutations that impair DNA binding. On the other hand, the p53-related p63 and p73 genes are rarely mutated, but many cell types express natural variants lacking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15060172
DOI: 10.1128/MCB.24.8.3536-3551.2004
PMCID: PMC381690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15060172-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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