Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes.

doi:10.1016/S0079-6123(10)82001-1

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Article

Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes.

Progress in brain research - 1 Jan 2010

Smith Lindsay K, Cidlowski John A

Abstract excerpt

Glucocorticoids exert a wide range of physiological effects, including the induction of apoptosis in lymphocytes. The progression of glucocorticoid-induced apoptosis is a multi-component process requiring contributions from both genomic and cytoplasmic signaling events. There is significant evidence indicating that the transactivation activity of the glucocorticoid receptor is required for the initiation of...

Topics

Apoptosis
Gene Expression Regulation
Glucocorticoids
Hematologic Neoplasms
Humans
Lymphocytes
Lymphoma, Non-Hodgkin
Male
Models, Biological
Multiple Myeloma
Mutation
Receptors, Glucocorticoid
Signal Transduction

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Identifiers

PMID: 20541659
DOI: 10.1016/S0079-6123(10)82001-1
PMCID: PMC4770454

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