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Article

Site-directed mutations in the Sindbis virus E2 glycoprotein identify palmitoylation sites and affect virus budding.

Journal of virology - 1 May 1993

Ivanova L, Schlesinger M J

Abstract excerpt

The assembly and budding of Sindbis virus, a prototypic member of the alphavirus subgroup in the family Togaviridae, requires a specific interaction between the nucleocapsid core and the membrane-embedded glycoproteins E1 and E2. These glycoproteins are modified posttranslationally by the addition of palmitic acid, and inhibitors of acylation interfere with this budding process (M.J. Schlesinger and C. Malfer, J....

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Identifiers

PMID: 8474160
DOI: 10.1128/JVI.67.5.2546-2551.1993
PMCID: PMC237574

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