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Growth Rate Changes in CHO Host Cells Are Associated with Karyotypic Heterogeneity

2 Sept 2017

Abstract excerpt

Chinese hamster ovary (CHO) cell line instability and clonality issues can affect cell culture phenotypes such as cell growth, productivity, or product quality and remain challenges for biopharmaceutical manufacturing. While there have been efforts for characterizing cell line instability in CHO production cell lines, a pre-existing level of cell line instability in CHO host cells has not been determined. In this...

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PMID: 28865132
DOI: 10.1002/biot.201700230

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