Article
Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado.
American journal of clinical pathology - 1 Feb 1995
Enomoto T, Fujita M, Inoue M, Nomura T, Shroyer K R
Abstract excerpt
The authors previously reported a significant frequency of activating point mutations in codon 12 and 13 of the K-ras gene in endometrial carcinoma and endometrial atypical hyperplasia from Osaka, Japan. They also showed that alterations of the p53 gene are found frequently in those tumors. This study was designed to reveal possible demographic differences in the prevalence of K-ras and p53 mutations in...
Topics
- Adenocarcinoma
- Base Sequence
- Colorado
- Endometrial Neoplasms
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation