Article
K-ras mutation in tamoxifen-related endometrial polyps.
Cancer - 1 Nov 2003
Hachisuga Toru, Miyakawa Takashi, Tsujioka Hiroshi, Horiuchi Shinji, Emoto Makoto, Kawarabayashi Tatsuhiko
Abstract excerpt
BACKGROUND: K-ras mutation is thought to occur at an early stage of neoplastic progression in the endometrium. The authors investigated mutations in codon 12 of K-ras in tamoxifen (TAM)-related endometrial polyps. METHODS: DNA was extracted from 11 frozen endometrial polyps from TAM-treated patients with breast carcinoma. Mutations were detected using the mutant allele-specific amplification method. The results...
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