Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development.

The Journal of investigative dermatology - 1 Jun 2016

Turkoz Mustafa, Townsend R Reid, Kopan Raphael

Abstract excerpt

Ligand-dependent activation, γ-secretase-processed cleavage, and recombining binding protein Jk (RBPj)-mediated downstream transcriptional activities of Notch receptors constitute the "canonical" Notch signaling pathway, which is essential for skin organogenesis. However, in Msx2-Cre mice, keratinocyte-specific deletion of the Rbpj gene in utero produced a significantly milder phenotype than either global Notch...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial Cells
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hair Follicle

Share to Immunoglobulin J Recombination Signal Sequence-Binding Protein

Share to Mice, Transgenic

Share to Real-Time Polymerase Chain Reaction

Share to Receptors, Notch

Source

Open in PubMed Open full text

Identifiers

PMID: 26940862
DOI: 10.1016/j.jid.2016.02.018
PMCID: PMC5036938

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development.PMID 26940862Read ↗

Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal IntegritySemantic proximity Read ↗

Disruption of Smad4 in mouse epidermis leads to depletion of follicle stem cells.Semantic proximity Read ↗

Notch signaling in the embryonic ectoderm promotes periderm cell fate and represses mineralization of vibrissa hair folliclesSemantic proximity Read ↗

Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumoursSemantic proximity Read ↗

Dicer- and BSC-dependent miRNAs during murine anagen developmentSemantic proximity Read ↗

Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signalingSemantic proximity Read ↗

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.Semantic proximity Read ↗

Adam10 haploinsufficiency causes freckle-like macules in Hairless mice.Semantic proximity Read ↗

Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in miceSemantic proximity Read ↗

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.Semantic proximity Read ↗

Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian EpidermisSemantic proximity Read ↗

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.