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Article

Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis.

The New England journal of medicine - 13 Jun 1991

Omata M, Ehata T, Yokosuka O, Hosoda K, Ohto M

Abstract excerpt

BACKGROUND: The presence of the hepatitis B e antigen (HBeAg) in serum is known to be a marker of a high degree of viral infectivity. However, fulminant hepatitis may occur in persons who are negative for HBeAg. A single point mutation has been reported to produce a stop codon in the precore region of hepatitis B virus DNA and prevent the formation of the precore protein required to make HBeAg. To determine...

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Identifiers

PMID: 2034246
DOI: 10.1056/NEJM199106133242404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis.PMID 2034246Read ↗

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Novel mutation in Hepatitis B virus preventing HBeAg production and resembling primate strains.Semantic proximity Read ↗

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Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity.Semantic proximity Read ↗

Point mutation in precore region of hepatitis B virus: sequential changes from 'wild' to 'mutant'.Semantic proximity Read ↗

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