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Article

Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis.

The New England journal of medicine - 13 Jun 1991

Omata M, Ehata T, Yokosuka O, Hosoda K, Ohto M

Abstract excerpt

BACKGROUND: The presence of the hepatitis B e antigen (HBeAg) in serum is known to be a marker of a high degree of viral infectivity. However, fulminant hepatitis may occur in persons who are negative for HBeAg. A single point mutation has been reported to produce a stop codon in the precore region of hepatitis B virus DNA and prevent the formation of the precore protein required to make HBeAg. To determine...

Topics

Acute Disease
Adult
Aged
Amino Acid Sequence
Base Sequence
Chronic Disease
Codon
DNA, Viral
Female
Hepatitis B
Hepatitis B Antibodies
Hepatitis B e Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 2034246
DOI: 10.1056/NEJM199106133242404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2034246-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis.PMID 2034246Read ↗

Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States.Semantic proximity Read ↗

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Fulminant hepatitis B: induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen.Semantic proximity Read ↗

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Novel mutation in Hepatitis B virus preventing HBeAg production and resembling primate strains.Semantic proximity Read ↗

Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France.Semantic proximity Read ↗

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Differences in the entire nucleotide sequence between hepatitis B virus genomes from carriers positive for antibody to hepatitis B e antigen with and without active disease.Semantic proximity Read ↗

Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis.Semantic proximity Read ↗

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