Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

American journal of human genetics - 1 Mar 1993

Spielman R S, McGinnis R E, Ewens W J

Abstract excerpt

A population association has consistently been observed between insulin-dependent diabetes mellitus (IDDM) and the "class 1" alleles of the region of tandem-repeat DNA (5' flanking polymorphism [5'FP]) adjacent to the insulin gene on chromosome 11p. This finding suggests that the insulin gene region contains a gene or genes contributing to IDDM susceptibility. However, several studies that have sought to show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Analysis of Variance
Share to Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Genetic Carrier Screening

Share to Genetic Markers

Share to Linkage Disequilibrium

Share to Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 8447318
PMCID: PMC1682161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).PMID 8447318Read ↗

A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test.Semantic proximity Read ↗

Informative-transmission disequilibrium test (i-TDT): combined linkage and association mapping that includes unaffected offspring as well as affected offspring.Semantic proximity Read ↗

Pedigree tests of transmission disequilibrium.Semantic proximity Read ↗

A sib-pair regression model of linkage disequilibrium for quantitative traits.Semantic proximity Read ↗

Transmission disequilibrium test (TDT) when only one parent is available: the 1-TDT.Semantic proximity Read ↗

Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.Semantic proximity Read ↗

TDT statistics for mapping quantitative trait loci.Semantic proximity Read ↗

Testing linkage disequilibrium in sibships.Semantic proximity Read ↗

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.Semantic proximity Read ↗

Exact transmission-disequilibrium tests with multiallelic markers.Semantic proximity Read ↗

The analysis of parental origin of alleles may detect susceptibility loci for complex disorders.Semantic proximity Read ↗

Evaluating linkage and linkage disequilibrium: use of excess sharing and transmission disequilibrium methods in affected sib pairs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.