Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.

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Article

Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.

American journal of human genetics - 1 May 1994

Owerbach D, Gabbay K H

Abstract excerpt

Ninety-six multiplex type I diabetic families were typed at the 5' flanking region of the insulin gene by using a PCR assay that better resolves the VNTR into multiple alleles. Affected sibling pairs shared 2, 1, and 0 VNTR alleles--identical by descent--at a frequency of .47, .45, and .08, respe...

Topics

Age of Onset
Alleles
Base Sequence
Child
Chromosome Mapping
Chromosomes, Human, Pair 11
Consensus Sequence
Diabetes Mellitus, Type 1
Genetic Linkage
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DR Antigens
Humans
Insulin
Molecular Sequence Data
Nuclear Family
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

Source

Open in PubMed Open full text

Identifiers

PMID: 7909987
PMCID: PMC1918272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7909987-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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