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Article

Evolution of bacteriophage T7 in a growing plaque.

Journal of bacteriology - 1 Mar 1993

Yin J

Abstract excerpt

The emergence of mutants during the 10(9)-fold amplification of a bacteriophage was spatially resolved in a growing plaque. When wild-type phage T7 was grown on an Escherichia coli host which expressed an essential early enzyme of the phage infection cycle, the T7 RNA polymerase, mutant phage relying on this enzyme appeared in 10(8) phage replications and outgrew the wild type. Spatial resolution of the selection...

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Identifiers

PMID: 8444789
DOI: 10.1128/jb.175.5.1272-1277.1993
PMCID: PMC193211

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