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Article

Protease treatment of nuclear extracts distinguishes between class II MHC X1 box DNA-binding proteins in wild-type and class II-deficient B cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1993

Hasegawa S L, Riley J L, Sloan J H, Boss J M

Abstract excerpt

The X box region is critical for directing the expression of class II major histocompatibility complex genes in B lymphocytes. Although several class II promoter-specific DNA binding factors have been described, only the X box region factor, RFX, shows a genetic correlation with class II expression, being deficient in some B cell lines derived from patients with class II-deficient congenital immunodeficiency. To...

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PMID: 8436816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Protease treatment of nuclear extracts distinguishes between class II MHC X1 box DNA-binding proteins in wild-type and class II-deficient B cells.PMID 8436816Read ↗

The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.Semantic proximity Read ↗

Reversion of a transcriptionally defective MHC class II-negative human B-cell mutant.Semantic proximity Read ↗

Defective HLA DRA X box binding in the class II transactive transcription factor mutant 6.1.6 and in cell lines from class II immunodeficient patients.Semantic proximity Read ↗

Class II MHC transcriptional mutants are defective in higher order complex formation.Semantic proximity Read ↗

Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complexSemantic proximity Read ↗

A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.Semantic proximity Read ↗

Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX.Semantic proximity Read ↗

The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor.Semantic proximity Read ↗

Regulatory factor-X binding to mutant HLA-DRA promoter sequences.Semantic proximity Read ↗

Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells.Semantic proximity Read ↗

In vivo ultraviolet and dimethyl sulfate footprinting of the 5' region of the expressed and silent Xist alleles.Semantic proximity Read ↗

Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.Semantic proximity Read ↗

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