Article
Effect of the AIR-1 locus on the activation of an enhancerless HLA-DQA1 promoter.
Immunogenetics - 1 Jan 1990
Ombra M N, Del Pozzo G, Perfetto C, Maffei A, Guardiola J
Abstract excerpt
Studies on the regulation of a major histocompatibility complex (MHC) class II gene, HLA-DQA1, in Ia-positive cells (Raji, a human B-lymphoma cell line) and in isogenic Ia-negative cells (RJ2.2.5, a mutant of Raji altered at the AIR-1 locus) are reported. As previously found, AIR-1 is required in its entirety for the activity of an enhancer factor, the absence of which abolishes transcription of MHC class II...
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