Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.

doi:10.1002/j.1460-2075.1994.tb06824.x

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Article

Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.

The EMBO journal - 17 Oct 1994

Zimber-Strobl U, Strobl L J, Meitinger C, Hinrichs R, Sakai T, Furukawa T, Honjo T, Bornkamm G W

Abstract excerpt

Epstein-Barr virus nuclear antigen 2 (EBNA-2) plays a crucial role in B cell immortalization by Epstein-Barr virus (EBV), most probably by its ability to transactivate several cellular and viral genes. Recently, we showed that EBNA-2 interacts with the TP1 promoter of EBV through a cellular protein. In this report we provide evidence that this protein is recombination signal binding protein (RBP)-J kappa, highly...

Topics

3T3 Cells
Animals
Antigens, Viral
Base Sequence
Cell Line
Chromatography, Affinity
DNA-Binding Proteins
Epstein-Barr Virus Nuclear Antigens
Herpesvirus 4, Human
Immunoglobulin J Recombination Signal Sequence-Binding Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Nuclear Proteins

Promoter Regions, Genetic

Protein Binding

Trans-Activators

Source

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Identifiers

PMID: 7957063
DOI: 10.1002/j.1460-2075.1994.tb06824.x
PMCID: PMC395438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7957063-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.PMID 7957063Read ↗

Both Epstein-Barr Viral Nuclear Antigen 2 (EBNA2) and Activated Notch1 Transactivate Genes by Interacting with the Cellular Protein RBP-JκSemantic proximity Read ↗

Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.Semantic proximity Read ↗

Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1.Semantic proximity Read ↗

EBP2, a human protein that interacts with sequences of the Epstein-Barr virus nuclear antigen 1 important for plasmid maintenance.Semantic proximity Read ↗

RBP-J<sub>k</sub>repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2Semantic proximity Read ↗

The Epstein‐Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis‐element of the terminal protein 1 gene promoter.Semantic proximity Read ↗

Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation.Semantic proximity Read ↗

Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2Semantic proximity Read ↗

The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor.Semantic proximity Read ↗

Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction.Semantic proximity Read ↗

Identification of Epstein-Barr Virus (EBV) Nuclear Antigen 2 (EBNA2) Target Proteins by Proteome Analysis: Activation of EBNA2 in Conditionally Immortalized B Cells Reflects Early Events after Infection of Primary B Cells by EBVSemantic proximity Read ↗

Direct Interaction between Nucleosome Assembly Protein 1 and the Papillomavirus E2 Proteins Involved in Activation of TranscriptionSemantic proximity Read ↗

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