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Article

Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes.

Molecular medicine (Cambridge, Mass.) - 1 Jan 2011

Newrzela Sebastian, Cornils Kerstin, Heinrich Tim, Schläger Julia, Yi Ji-Hee, Lysenko Olga, Kimpel Janine, Fehse Boris, von Laer Dorothee

Abstract excerpt

Several cases of T-cell leukemia caused by gammaretroviral insertional mutagenesis in children treated for x-linked severe combined immunodeficiency (SCID) by transplantation of autologous gene-modified stem cells were reported. In a comparative analysis, we recently showed that mature T cells, on the contrary, are highly resistant to transformation by gammaretroviral gene transfer. In the present study, we...

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Source

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Identifiers

PMID: 21826372
DOI: 10.2119/molmed.2010.00193
PMCID: PMC3321800

Genes

LMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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