Article
Autonomous growth of lymphoid cells following IL-2 expression from retrovirus vectors containing HIV-1 trans-acting elements.
Somatic cell and molecular genetics - 1 Jan 1990
Shapiro I M, Meier C, Vlach V, McDonald T L, Wigzell H, Stevenson M
Abstract excerpt
The human immunodeficiency virus type I (HIV-1) possesses powerful regulatory elements that control the rate of replication of HIV-1 and subsequent processing of HIV-1 genes. We have used this regulatory mechanism to drive expression of foreign genes inserted in retrovirus vectors. This approach...
Topics
- Animals
- Antibodies
- Cell Division
- Chloramphenicol O-Acetyltransferase
- Clone Cells
- Genes, tat
- Genetic Vectors
- HIV-1
- Humans
- Interleukin-2
- Mice
- Phenotype
- Receptors, Interleukin-2
- Recombinant Proteins
- Retroviridae
- T-Lymphocytes, Cytotoxic
- Transcriptional Activation