Article
CRE and TRE sequences of the rat tyrosine hydroxylase promoter are required for TH basal expression in adult mice but not in the embryo.
The European journal of neuroscience - 1 Feb 1998
Trocmé C, Sarkis C, Hermel J M, Duchateau R, Harrison S, Simonneau M, Al-Shawi R, Mallet J
Abstract excerpt
Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, is expressed in a restricted number of areas, and subject to numerous regulations during development and in adulthood. Two transcription factor binding sites present in the proximal region...
Topics
- Adrenal Medulla
- Aging
- Animals
- Brain
- Brain Chemistry
- Coloring Agents
- Cyclic AMP Response Element Modulator
- DNA-Binding Proteins
- Female
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Enzymologic
- Immunohistochemistry
- Mice
- Mutation