Article
CRE and TRE sequences of the rat tyrosine hydroxylase promoter are required for TH basal expression in adult mice but not in the embryo.
The European journal of neuroscience - 1 Feb 1998
Trocmé C, Sarkis C, Hermel J M, Duchateau R, Harrison S, Simonneau M, Al-Shawi R, Mallet J
Abstract excerpt
Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, is expressed in a restricted number of areas, and subject to numerous regulations during development and in adulthood. Two transcription factor binding sites present in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been shown to play...
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