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Article

The DNA replication priming protein, PriA, is required for homologous recombination and double-strand break repair.

Journal of bacteriology - 1 Mar 1996

Kogoma T, Cadwell G W, Barnard K G, Asai T

Abstract excerpt

The PriA protein, a component of the phiX174-type primosome, was previously shown to be essential for damage-inducible DNA replication in Escherichia coli, termed inducible stable DNA replication. Here, we show that priA::kan null mutants are defective in transductional and conjugational homologous recombination and are hypersensitive to mitomycin C and gamma rays, which cause double-strand breaks. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8631700
DOI: 10.1128/jb.178.5.1258-1264.1996
PMCID: PMC177797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The DNA replication priming protein, PriA, is required for homologous recombination and double-strand break repair.PMID 8631700Read ↗

Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication.Semantic proximity Read ↗

Escherichia coli K-12 has two distinguishable PriA-PriB replication restart pathways.Semantic proximity Read ↗

ATPase-deficient mutants of the Escherichia coli DNA replication protein PriA are capable of catalyzing the assembly of active primosomes.Semantic proximity Read ↗

Differential suppression of priA2::kan phenotypes in Escherichia coli K-12 by mutations in priA, lexA, and dnaC.Semantic proximity Read ↗

Mutational Analysis of Residues in PriA and PriC Affecting Their Ability To Interact with SSB in Escherichia coli K-12.Semantic proximity Read ↗

dnaC mutations suppress defects in DNA replication- and recombination-associated functions in priB and priC double mutants in Escherichia coli K-12.Semantic proximity Read ↗

Purification and characterization of DnaC810, a primosomal protein capable of bypassing PriA function.Semantic proximity Read ↗

ATPase/helicase motif mutants of Escherichia coli PriA protein essential for recombination-dependent DNA replication.Semantic proximity Read ↗

PriA mutations that affect PriA-PriC function during replication restart.Semantic proximity Read ↗

Restart of DNA replication in Gram-positive bacteria: functional characterisation of the Bacillus subtilis PriA initiator.Semantic proximity Read ↗

Multiple genetic pathways for restarting DNA replication forks in Escherichia coli K-12.Semantic proximity Read ↗

Allele specific synthetic lethality between priC and dnaAts alleles at the permissive temperature of 30 degrees C in E. coli K-12.Semantic proximity Read ↗

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