Article
Alleles of the homologous recombination gene, RAD59, identify multiple responses to disrupted DNA replication in Saccharomyces cerevisiae.
BMC microbiology - 14 Oct 2013
Liddell Lauren C, Manthey Glenn M, Owens Shannon N, Fu Becky X H, Bailis Adam M
Abstract excerpt
BACKGROUND: In Saccharomyces cerevisiae, Rad59 is required for multiple homologous recombination mechanisms and viability in DNA replication-defective rad27 mutant cells. Recently, four rad59 missense alleles were found to have distinct effects on homologous recombination that are consistent with separation-of-function mutations. The rad59-K166A allele alters an amino acid in a conserved α-helical domain, and,...
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